Rancho BioSciences Grants Software for Protein Array Analysis to the Research Community

By CIOReview | Wednesday, February 17, 2016

FREMONT, CA: Rancho BioSciences, a fee-for-service data curation organization, has announced the donation of software for analysis of protein microarrays to general scientific research community. Previously, the automation of analysis was not possible as the researches on arrays like Invitrogen's ProtoArray platform required the use of point-and-click vendor-supplied tools. However, now the proprietary software is no longer required and overall analysis can be automated with the assistance of an open source bioinformatics platform Bioconductor, based on the R programming language. This automation was achieved with the aid of a Bioconductor package named Protein Array Analyzer (PAA) for examining ProtoArrays and various protein arrays, funded as part of de.NBI by the German Federal Ministry of Education and Research. Presently, PAA v1.4.1 applies crucial methods like robust linear model (RLM) normalization and M-statistic calculation to attain more dependable outcomes.

The recent code of Rancho incorporates operations for M-static calculation and RLM normalization. The current PAA format is equipped with identical functions for the before mentioned two methods, keeping these functions unaltered. Michael Turewicz, Scientific Assistant at Ruhr-University Bochum, Germany appreciated the latest elements of PAA Bioconductor platform. He said, “Rancho's customizations regarding a better results visualization and improved batch filtering provide valuable new features to the PAA package for the analysis of protein array experiments.”

“Bioconductor has been valuable to the scientific community for years, and this contribution to PAA brings improved analysis options to the protein array field,” said Dr. John Obenauer, Head of Bioinformatics at Rancho as he acknowledged the perks of delivering code to open source software.